Advanced nanoformulations against bacterial infection

Yeast Protects Against Bacterial Infection

Since 1940 when we began a study of sensitization in laboratory animals treated with pertussis vaccine we have emphasized the role of the bacterial protein in this phenomenon. Considerable information has been accumulated which indicates that vaccination with Hemnophilus pertussis, while increasing resistance against infection by the same organism will, at the same time, produce hypersensitivit...

Advanced drug delivery to the lymphatic system: lipid-based nanoformulations

The delivery of drugs and bioactive compounds via the lymphatic system is complex and dependent on the physiological uniqueness of the system. The lymphatic route plays an important role in transporting extracellular fluid to maintain homeostasis and in transferring immune cells to injury sites, and is able to avoid first-pass metabolism, thus acting as a bypass route for compounds with lower b...

Inhibitory Influence of Chronic Amœbiasis on Immunity against Bacterial Infection

Cathelicidins and innate defense against invasive bacterial infection.

Cathelicidins are small cationic peptides that possess broad-spectrum antimicrobial activity. These gene-encoded 'natural antibiotics' are produced by several mammalian species on epithelial surfaces and within the granules of phagocytic cells. Since their discovery over a decade ago, cathelicidins have been speculated to function within the innate immune system, contributing to a first line of...

Scaling of immune responses against intracellular bacterial infection.

Macrophages detect bacterial infection through pattern recognition receptors (PRRs) localized at the cell surface, in intracellular vesicles or in the cytosol. Discrimination of viable and virulent bacteria from non-virulent bacteria (dead or viable) is necessary to appropriately scale the anti-bacterial immune response. Such scaling of anti-bacterial immunity is necessary to control the infect...